Anaplastic Astrocytoma (AA) and Glioblastoma (GBM): a real-life experience in Padua
نویسندگان
چکیده
منابع مشابه
A 16-Gene Signature Distinguishes Anaplastic Astrocytoma from Glioblastoma
Anaplastic astrocytoma (AA; Grade III) and glioblastoma (GBM; Grade IV) are diffusely infiltrating tumors and are called malignant astrocytomas. The treatment regimen and prognosis are distinctly different between anaplastic astrocytoma and glioblastoma patients. Although histopathology based current grading system is well accepted and largely reproducible, intratumoral histologic variations of...
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Human malignant gliomas are thought to develop as the result of stepwise accumulations of multiple genetic alterations. Recently, we showed that E6/E7-mediated inactivation of p53/pRb, ras pathway activation (initiated by expression of mutant H-Ras), and expression of human telomerase reverse transcriptase (hTERT) in combination converted normal human astrocytes into cells that formed intracran...
متن کاملPTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme.
BACKGROUND Survival of patients with anaplastic astrocytoma is highly variable. Prognostic markers would thus be useful to identify clinical subsets of such patients. Because specific genetic alterations have been associated with glioblastoma, we investigated whether similar genetic alterations could be detected in patients with anaplastic astrocytoma and used to identify those with particularl...
متن کاملGlioma Glioblastoma Multiforme in a Human Astrocyte Model of Akt Pathway Activation Converts Anaplastic Astrocytoma to
Human malignant gliomas are thought to develop as the result of stepwise accumulations of multiple genetic alterations. Recently, we showed that E6/E7-mediated inactivation of p53/pRb, ras pathway activation (initiated by expression of mutant H-Ras), and expression of human telomerase reverse transcriptase (hTERT) in combination converted normal human astrocytes into cells that formed intracran...
متن کاملIntratumoral Adjuvant Chemotherapy With Doxorubicine In Glioblastoma Multiforme and Anaplastic Astrocytoma
Intratumoralloeal chemotherapy was applied as adjuva nt treatment to 20 patient with reeurrent types of anaplastic astroeytoma (AG3-4) and glioblastoma multiforme (GBM). A multiport catheter was implanted into the tumour and a portable Ammaya reservoir was plaeed under the sealp over the ap en eraniotomy bone flap. Doxorubidne (Adriamydne) was given 0.5mg per day for ten day s ,and a total of t...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2016
ISSN: 0923-7534
DOI: 10.1093/annonc/mdw345.23